fmoc-L-isoleucine pentafluorophenyl ester

fmoc-L-isoleucine pentafluorophenyl ester - Names and Identifiers

Name	fmoc-L-isoleucine pentafluorophenyl ester
Synonyms	FMOC-ILE-OPFP Fmoc-Ile-OPfp Fmoc-L-Ile-OPfp FMOC-ISOLEUCINE-OPFP FMOC-L-ISOLEUCINE PENTAFLUOROPHENYL ESTER fmoc-L-isoleucine pentafluorophenyl ester N-ALPHA-FMOC-L-ISOLEUCINE PENTAFLUOROPHENYL ESTER N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl NALPHA-9-Fluorenylmethoxycarbonyl-L-isoleucine pentafluorophenyl ester N-alpha-(9-fluorenylmethyloxycarbonyl)-L-isoleucine pentafluorphenyl ester (2S,3S)-perfluorophenyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylpentanoate (2,3,4,5,6-pentafluorophenyl) (2S,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-pentanoate
CAS	86060-89-1
InChI	InChI=1/C27H22F5NO4/c1-3-13(2)24(26(34)37-25-22(31)20(29)19(28)21(30)23(25)32)33-27(35)36-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18,24H,3,12H2,1-2H3,(H,33,35)/t13-,24-/m0/s1

fmoc-L-isoleucine pentafluorophenyl ester - Physico-chemical Properties

Molecular Formula	C27H22F5NO4
Molar Mass	519.46
Density	1.35g/cm³
Melting Point	73-75℃
Boling Point	596.3°C at 760 mmHg
Flash Point	314.5°C
Vapor Presure	3.47E-14mmHg at 25°C
BRN	4221390
Storage Condition	2-8°C
Refractive Index	1.549

fmoc-L-isoleucine pentafluorophenyl ester - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	2924 29 70

fmoc-L-isoleucine pentafluorophenyl ester - Introduction

fmoc-L-isoleucine pentafluorophenyl (fmoc-L-isoleucine pentafluorophenyl ester) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless to light yellow solid
-Molecular formula: C34H29F5NO4
-Molecular weight: 619.59g/mol
-melting point: about 110-120 ℃
-Solubility: Soluble in organic solvents such as dichloromethane, dimethylformamide

Use:
- fmoc-L-isoleucine pentafluorophenyl ester is commonly used in peptide synthesis in solid phase synthesis. It acts as an activator and can react with an amino acid or a carboxyl group of a polypeptide, thereby introducing fmoc-L-isoleucine into the polypeptide chain.

Preparation Method:
- fmoc-L-isoleucine pentafluorophenyl ester can be obtained by reacting fmoc-L-isoleucine with pentafluorophenol esterifying agent (such as pentafluorophenyl trifluoroacetate). The specific steps include adding the pentafluorophenol esterifying agent to N,N-dimethylformamide at frozen room temperature, then adding fmoc-L-isoleucine and stirring, then adding carbodiimide, and finally adding sodium hydroxide to adjust the pH value to obtain the target product.

Safety Information:
- fmoc-L-isoleucine pentafluorophenyl ester belongs to chemical reagents, should be careful operation. Proper laboratory practices should be observed during use, including the wearing of appropriate protective equipment (e. g., lab clothes, gloves, goggles, etc.).
-Avoid inhalation, ingestion or contact with skin and eyes. If exposed, rinse immediately with water and seek medical help.
-Keep sealed storage and avoid contact with oxygen, flammable substances, etc. to prevent fire or explosion hazards.
-Please dispose of the waste of this compound properly and follow the relevant local waste disposal regulations.

Last Update：2024-04-10 22:29:15